Acne Infections
Acne starts during adolescence when your body activates your sebum glands to produce an oily substance that when on the surface of the skin it lubricates it and shields your skin from infection by pathogens that thrive there permanently. If sebum does not outflow freely through the sebum canals to the exterior it produces multiple skin injuries that initiate an inflammatory reaction and the sebum accumulated there becomes a perfect feeding ground for the growth of microbes.
The skin is confronted with heavy demands when one of these infections occur. Areas with recurrent acne infections caused by moderate or severe acne commonly develop deficiencies of basic ingredients, impairing the skin's capability to defend itself and heal efficiently.
Acne infections damage collagen and elastin fibers, interrupt the microvascular system and damage and kill cells. When healing happens, usually after a long time if a proper acne treatment has not be applied, a scar is left in the skin. The healthy functional tissue (skin) is replaced by connective tissue (scar).
Organic Ingredient Treats Acne
Bacteria have survived for millions of years by developing resistance to new stressors including natural antibiotics like penicillin. What simply happens is that the bacteria, with a high rate of mutation, ends up changing one or more of its enzymes that are used to destroy the link between a target protein and the antibiotic. As a result, the antibiotic does not have effect.
But this system fails when the attacker punches holes in the cell membrane, as peptide antibiotics do. To defend itself, the bacterium would have to change the entire structure of the cell membrane. And to change the structure of a membrane would imply modifying most of the enzymes that are responsible for making the complex membrane in the first place.
Peptide antibiotics respond within minutes helping treat acne instantly. Part of the reason for this rapid response is how the peptide works on the cell membrane. But to destroy a cell, the peptide must also quickly locate the bacterial membrane. How does this happen? The answer lies in the construction of the cellular membrane.
The plasma membrane of eukaryotic cells is very different from the membrane of a prokaryotic cell. Eukaryotic cell walls are constructed of a phospholipid bilayer and cholesterol. Consequently, these walls have a low negative electrical charge. On the other hand, a bacterial membrane is composed by fats and sugars. This difference in construction means that bacteria have a high negative electrical charge that quickly attracts the peptide antibiotics.
Peptide antibiotics are effective. In one clinical trial for the treatment of meningitis, a sickness that affects 3,000 children a year, a peptide antibiotic not only destroyed the bacterium which produces the toxin, but it also bound to the toxin avoiding the damage the endotoxin produces. But bringing a new drug to clinical trial is time consuming and costly. It takes $300 million to bring a drug to market. This price covers every thing from discovery, identification, production and clinical trials. This process can also take ten or more years to accomplish.
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Published November 20th, 2007